Cannabis

Pronunciation: kan-uh-bis

 

According to sources, this medicine is used for a wide variety of ailments. Currently, controlled trials are taking place and more scientific information on the therapeutic effects of cannabis is being established.

 

Some of the more accepted medical conditions that benefit from the effects of cannabis are:

 

Alzheimer's Disease: reduces agitation and insomnia; stimulates weight gain

 

Amyotrophic Lateral Sclerosis: slows disease progression, reduces pain, appetite loss, depression, and drooling

 

Chronic Pain: reduces nerve-related (neuropathic) pain, opioid treatment available at lower doses

 

Diabetes Mellitus: slows disease progression, protects from eye disease, reduce neuropathic (nerve) pain, reduces symptoms of heart-muscle disease (cardiomyopathy)

 

Dystonia: reduces muscle tension and involuntary, painful muscle contractions

 

Fibromyalgia: reduces pain and muscle stiffness, improves sleep quality

 

Gastrointestinal Disorders: reduces cramping, abdominal pain, acid reflux, intestinal secretion, and disease activity

 

Glaucoma: reduces intraocular (eye) pressure

 

Gliomas/Cancer: inhibits tumor growth, reduces nausea and vomiting from cancer chemotherapy

 

HIV/AIDS: reduces neuropathic pain, anxiety, nausea, appetite, and weight loss

 

Incontinence: improves bladder control, reduce bladder inflammation/over-activity.

 

Multiple Sclerosis: reduces pain, spasticity, depression, fatigue, and incontinence

 

Parkinson's Disease: alleviates L-dopa induced dyskinesias (L D), reduce tremor, rigidity, and psychosis symptoms

 

Pruritus: reduces itching in conditions such as kidney and liver diseases

 

Rheumatoid Arthritis: reduces joint pain and swelling while suppressing joint destruction and disease worsening

 

Insomnia: induces sleep and/or improves sleep quality.

 

Tourette's Syndrome: improvement of tics and obsessive- compulsive behavior.

 

Suggested Active Compounds of Cannabis:

Cannabichromene (CBC), Cannabidiol (CBD), Cannabidiolic acid (CBDA), Cannabidivarin (CBDV), Cannabigerol (CBG), Cannabinol (CBN), Tetrahydrocannabinol (THC), Tetrahydrocan- nabinolic acid (THCA), Tetrahydrocannabivarin (THCV), Terpenoids.

 

 

 

Other Compounds:

There may be more than 60 other cannabinoids and more than 200 terpenoids in cannabis.

 

Cannabis Forms:

• Dried plant material

• Concentrate

• Topical salve, edible (including drinks)

 

Do NOT USE Cannabis if:

• You are allergic to any cannabinoid or terpenoid

• You have a history of serious mental disorder such as schizophrenia or severe depression

• You are pregnant or planning to get pregnant; in addition to the risk of smoking, the use of cannabis when you are pregnant may be a risk factor for sudden infant death syndrome and uterine exposure to cannabis may also cause behavioral problems in the child

• You are nursing (breastfeeding)

 

IMPORTANT: there may be other conditions where this product should not be used but which are unknown due to limited scientific information.

 

BEFORE USING cannabis:

ALWAYS TALK TO YOUR PHYSICIAN, PARTICULARLY IF:

• You have heart disease

• You have asthma, chronic obstructive pulmonary disease or other disease of the airways

• You have a history of alcohol abuse or dependence

• You have a history of drug abuse or dependence

• You have a history of a serious mental disorder

 

How to Use This Medicine

According to sources, patients must use this cannabis as directed by your doctor. Dosage and frequency of administration will vary according to route of administration and percentage of therapeutic ingredients, and other medicines taken. Ask your doctor or patient advisor to explain what dosage, route, and frequency is best for you. Remember that concentrates have higher dosages per weight of medicine than other forms. Make sure you give the medicine sufficient time to take effect. This is especially important with the edible form of cannabis where therapeutic effect may take up to 1-2 hours before taking effect. Eating too much medicine too fast may easily occur causing unwanted side effects. Use this medicine only for the length of time recommended by your doctor. It is not recommended to use this medicine in combination with tobacco.

 

Important SAFETY INFORMATION About This Medicine

• If you have not consumed cannabis before, it would be prudent to have someone with you the first time you use it. Start with small quantities. Stop using this medication if you begin to feel confused or agitated.

•After you stop using cannabis, it remains in your system for several weeks-to-months. During this time, tests that screen for cannabis may be positive.

•Cannabis may interact with several drugs. Tell your doctor which prescription drugs, nonprescription drugs, and herbal products you are currently taking, particularly:

◦ Any drugs that slow down the central nervous system, causing drowsiness. This may include     sleeping pills, tranquilizers, some pain medications, some antihistamines, cold medications or seizure medications.

   ◦ Antiviral drugs used in the treatment of HIV/A DS.

•CANNABIS MAY IMPAIR YOUR ABLITY TO DRIVE OR OPERATE HEAVY MACHINERY. This can last up to 24 hours after consuming.

 

Possible SIDE EFFECTS of This Medicine

From Initial use:

When you first start consuming cannabis, you may experience mood reactions such as euphoria, relaxation, time-distortion, perception of enhanced sensory experiences, loss of inhibitions, anxiety, paranoia, agitation, amnesia, delusions, or hallucinations

Fast heartbeat (particularly if you have heart disease)

Facial flushing, red eyes, dry mouth, or headache

Dizziness or faintness when you immediately stand

 

From Long-term use:

From inhalation, a wheezing or a chronic cough may occur

May impair short-term memory attention and concentration, though these effects usually disappear after cannabis usage period ends

 

If OVERDOSE is Suspected

It is possible that the above-mentioned side effects will occur. Usually these resolve themselves within a short period of time when medication is stopped. Often fresh air, staying hydrated, and eating will help. Contact your doctor immediately if symptoms persist.

 

Proper STORAGE of this Medicine

Store in a tightly closed container in a cool, safe, and secure place. Store away from heat, moisture and light.

 

 

GENERAL INFORMATION

KEEP THIS MEDICINE OUT OF REACH OF CHILDREN AND PETS.

 

• If you have any questions about this medicine, please talk with your doctor.

• This medicine is to be used only by the patient for whom it is recommended. Do not share it with other people. It is illegal under state law.

• If your symptoms do not improve or if they become worse, check with your doctor.

• Check with your collective consultant or Uncle Herb’s Health Center about how to dispose of unused medicine.

 

This information is a summary only. It does not contain all information about this medicine.

What Is Cannabichromene (CBC)?

Cannabichromene (CBC) has shown to have profound benefits, similar to cannbidiol (CBD) and tetrahydrocannabinol (THC). CBC stems from the all-important cannabigerolic acid (CBGA).

 

Cannabigerolic acid (CBGA) is often referred to as the “stem cell” of cannabinoids. It is the precursor to THC, CBD, and CBC.

 

From there, enzymes cause it to convert into cannabidiol carboxylic acid (CBDA), tetrahydrocannabinol carboxylic acid (THCA), or cannabichrome carboxylic acid (CBCA). In this case of CBCA, it passes through the CBC synthase, or the enzymes that get the specific process underway.

 

In order to get cannabichromene, decarboxylation must occur. Over time, or quickly if exposed to heat, the CBCA will lose a molecule of CO2; at this point it is considered CBC. The same process applies when developing THC and CBD.

 

The Benefits of Cannabichromene For Cancer

 Research suggests Cannabichromene, or CBC, could be very beneficial. According to Halent Labs, it’s believed to inhibit inflammation and pain and stimulate bone growth. For more information, please read this article.

 

Cannabichromene has already been a successful remedy for migraines and has shown signs in minimizing pain and inflammation. However, one of the most intriguing findings about cannabichromene is its relationship with cancer. CBC is believed to have anti-proliferative effects, meaning it inhibits the growth of cancerous tumors. This could be a result of its interaction with anandamide.

 

Anandamide is an endocannabinoid, meaning our body produces it naturally. It affects the CB1 receptors, as well as the CB2 receptors and has been found to fight against human breast cancer. CBC inhibits the uptake of anandamide, which allows it to stay in the blood stream longer.

 

In addition to CBC own benefits, it appears to work with the other cannabinoids to produce a synergistic effect; it gives merit to the saying, “the whole is greater than the sum of its parts.” Even though cannabichromene is found in much smaller concentrations than THC and CBD, its importance should not be overlooked

 

Cannabis is unique in many ways. Of all plants, it is the only genus known to produce chemical substances known as herbal cannabinoids. These cannabinoids are the psychoactive ingredients of marijuana.

 

 

About Marijuana

Tetrahydrocannabinol – THC

 

Delta-9 -trans-tetrahydrocannabinol — Delta-9 THC is the main psychotomimetic ingredient of marijuana. It occurs in almost all concentrations of cannabis. In very potent strains, carefully prepared marijuana can be 30 percent delta-9 THC by dry weight.

 

Delta 8-trans-tetrahydrocannabinol — Delta-8 THC is reported in low concentration, less than one percent of the delta-9 THC present. Its activity is slightly less than that of delta-9 THC. It may be an artifact of the extraction/analysis process. The term THC typically refers to delta-9 THC and delta-8 THC combined.

 

Cannabidiol – CBD

Cannabidiol - CBD also occurs in almost all strains of marijuana. Concentrations range from none, to about 95 percent of the total cannabinoids present. THC and CBD are the two most abundant naturally occurring cannabinoids. CBD is not psychotomimetic in the pure form, although it does have sedative, analgesic, and antibiotic properties.

 

In order for CBD to affect the euphoria, THC must be present in quantities ordinarily psychoactive. CBD can contribute to the euphoria by interacting with THC to potentiate (enhance) or antagonize (interfere or lessen) certain qualities of the euphoria.

 

CBD appears to potentiate the depressant effects of THC and antagonize its excitatory effects. CBD also delays the onset of the euphoria, but can make it last considerably longer.

 

Cannabinol – CBN

Cannabinol - CBN is the degradation (oxidative) product of THC. Fresh samples of marijuana contain very little CBN but curing, poor storage, or processing can cause much of the THC to be oxidized to CBN. Pure forms of CBN have at most 10 percent of the psychoactivity of THC.

 

Like CBD, it is suspected of potentiating certain aspects of the euphoria, although so far these affects appear to be slight. CBN seems to potentiate THC's disorienting qualities. In fact, with a high proportion of CBN an euphoric state may never be reached and can later cause drowsiness. A high CBN content in marijuana is not desirable since it represents a loss of 90 percent of the psychoactivity of its precursor THC.

 

 

The Three Types of Cannabinoids:

• Herbal: occur naturally only in the cannabis plant

• Endogenous: occur naturally in humans and other animals

• Synthetic: cannabinoids produced in a lab

 

Tetrahydrocannabivarin – THCV

Tetrahydrocannabivarin - THCV or THV is the propyl homologue of THC. The propyl cannabinoids have so far been found in some strains originating from Southeast and Central Asia and parts of Africa.

 

In one study, THCV made up to 48.23 percent (Afghanistan strain) and 53.69 percent (South Africa) of the cannabinoids found. It is quicker to dissipate than THC.

 

Cannabichromene – CBC

Cannabichromene - CBC is another major cannabinoid, although it is found in smaller concentrations than CBD and THC. It was previously believed that is a minor constituent, but more exacting analysis showed that the compound often reported as CBD may actually be CBC.

 

Relative to THC and CBD, its concentration in the plants is low, probably not exceeding 20 percent of total cannabinoids. CBC is believed not to be psychotomimetic in humans. However, its presence in plants is purportedly very potent and has led to the suspicion that it may be interacting with THC to enhance euphoria.

 

Cannabicyclol – CBL

Cannabicyclol (CBL) is a degradative product like CBN. During extraction, light converts Cannabichromene - CBC to Cannabicyclol CBL. There are no reports on its activity in humans, and it is found in small amounts, if at all, in fresh plant material.

 

Cannabinoids And Medicating With Cannabinoids

The marijuana euphoria is a complex experience that involves a wide range of responses. The euphoria is a subjective experience based in the individual and one's personality, mood, disposition, and experience with the cannabinoids. Given the person, the intensity of the euphoria depends primarily on the amount of THC present in the marijuana.

 

Cannabis products having a THC concentration of 5-10 percent would be considered a high quality product while 10-25 percent would be considered very good quality and over 25 percent would be excellent quality. In general, we use potency to mean the sum effects of the cannabinoids and the overall euphoria induced in order to medicate and reduce pain or medical symptoms.

 

Except for THCV in the pure form, other cannabinoids do not have much psychoactivity. A possibility for higher potency is that homologues of delta-9 THC with longer side chains at C-3 (and higher activity) might be found in certain marijuana strains. Compounds with longer side chains have been made in laboratories and their activity is sometimes much higher with estimates over 500 times that of natural delta-9 THC.

 

Different blends of cannabinoids account for the different qualities of intoxication produced by different strains of cannabis. The intensity of the euphoria depends primarily on the amount of delta-9 THC present and on the method of ingestion.

To better understand medical cannabis, it is important to be aware that the chemical compounds available in the plant change with how the plant is processed and administered. Potential therapeutic benefits will vary if the cannabis is processed/administered in raw (unheated), heated, or aged (degraded) form.

 

Understanding that the various compounds in cannabis may modulate each other in synergistic or antagonistic ways is important. For example, the cannabinoid CBD will lessen to some degree the psychotropic effects of the cannabinoid THC, while the terpenoid α-pinene will synergize the bronchodilator effects of inhaling THC. The complexity of this interaction means that medical cannabis should be seen in the light of an herbal medicine, where to extract a so-called “active ingredient” will not necessarily result in the full range of therapeutic effects, or may produce unwanted side effects that usually do not occur when the whole herb is administered.

 

Finally, knowing that each strain of cannabis has potentially vastly different proportions of cannabinoids and terpenoids, which is most often expressed in terms of color, smell, and taste, means that one needs to be strain specific when discussing cannabis as medicine.